CovidSeniorV1, Main, Exploration, bibRecord, 000106

Treatment of severe COVID-19 with human umbilical cord mesenchymal stem cells.

Identifieur interne : 000106 ( Main/Exploration ); précédent : 000105; suivant : 000107

Treatment of severe COVID-19 with human umbilical cord mesenchymal stem cells.

Source :

Stem cell research & therapy [ 1757-6512 ] ; 2020.

RBID : pubmed:32811531

Descripteurs français

KwdFr :
- Adulte (MeSH), Adulte d'âge moyen (MeSH), Betacoronavirus (isolement et purification), Betacoronavirus (pathogénicité), Cellules souches mésenchymateuses (cytologie), Cellules souches mésenchymateuses (métabolisme), Chine (MeSH), Cordon ombilical (cytologie), Femelle (MeSH), Humains (MeSH), Infections à coronavirus (mortalité), Infections à coronavirus (thérapie), Infections à coronavirus (virologie), Interleukine-6 (métabolisme), Mâle (MeSH), Numération des lymphocytes (MeSH), Pandémies (MeSH), Pneumopathie virale (mortalité), Pneumopathie virale (thérapie), Pneumopathie virale (virologie), Protéine C-réactive (métabolisme), Résultat thérapeutique (MeSH), Sujet âgé (MeSH), Taux de survie (MeSH), Thorax (imagerie diagnostique), Tomodensitométrie (MeSH), Transplantation de cellules souches mésenchymateuses (MeSH), Transplantation homologue (MeSH).
MESH :
- cytologie : Cellules souches mésenchymateuses, Cordon ombilical.
- imagerie diagnostique : Thorax.
- isolement et purification : Betacoronavirus.
- mortalité : Infections à coronavirus, Pneumopathie virale.
- métabolisme : Cellules souches mésenchymateuses, Interleukine-6, Protéine C-réactive.
- pathogénicité : Betacoronavirus.
- thérapie : Infections à coronavirus, Pneumopathie virale.
- virologie : Infections à coronavirus, Pneumopathie virale.
- Adulte, Adulte d'âge moyen, Chine, Femelle, Humains, Mâle, Numération des lymphocytes, Pandémies, Résultat thérapeutique, Sujet âgé, Taux de survie, Tomodensitométrie, Transplantation de cellules souches mésenchymateuses, Transplantation homologue.
Wicri :
- geographic : République populaire de Chine.

English descriptors

KwdEn :
- Adult (MeSH), Aged (MeSH), Betacoronavirus (isolation & purification), Betacoronavirus (pathogenicity), C-Reactive Protein (metabolism), China (MeSH), Coronavirus Infections (mortality), Coronavirus Infections (therapy), Coronavirus Infections (virology), Female (MeSH), Humans (MeSH), Interleukin-6 (metabolism), Lymphocyte Count (MeSH), Male (MeSH), Mesenchymal Stem Cell Transplantation (MeSH), Mesenchymal Stem Cells (cytology), Mesenchymal Stem Cells (metabolism), Middle Aged (MeSH), Pandemics (MeSH), Pneumonia, Viral (mortality), Pneumonia, Viral (therapy), Pneumonia, Viral (virology), Survival Rate (MeSH), Thorax (diagnostic imaging), Tomography, X-Ray Computed (MeSH), Transplantation, Homologous (MeSH), Treatment Outcome (MeSH), Umbilical Cord (cytology).
MESH :
- chemical , metabolism : C-Reactive Protein, Interleukin-6.
- geographic : China.
- cytology : Mesenchymal Stem Cells, Umbilical Cord.
- diagnostic imaging : Thorax.
- isolation & purification : Betacoronavirus.
- metabolism : Mesenchymal Stem Cells.
- mortality : Coronavirus Infections, Pneumonia, Viral.
- pathogenicity : Betacoronavirus.
- therapy : Coronavirus Infections, Pneumonia, Viral.
- virology : Coronavirus Infections, Pneumonia, Viral.
- Adult, Aged, Female, Humans, Lymphocyte Count, Male, Mesenchymal Stem Cell Transplantation, Middle Aged, Pandemics, Survival Rate, Tomography, X-Ray Computed, Transplantation, Homologous, Treatment Outcome.

Abstract

BACKGROUND

COVID-19 is a highly infectious respiratory disease. No therapeutics have yet been proven effective for treating severe COVID-19.

OBJECTIVES

To determine whether human umbilical cord mesenchymal stem cell infusion may be effective and safe for the treatment of severe COVID-19.

METHODS

Patients with severe COVID-19 were randomly divided into 2 groups: the standard treatment group and the standard treatment plus hUC-MSC infusion group. The incidence of progression from severe to critical illness, 28-day mortality, clinical symptom improvement, time to clinical symptom improvement, hematologic indicators including C-reactive protein, lymphocyte number, and interleukin 6, and imaging changes were observed and compared between the two groups.

MEASUREMENTS AND MAIN RESULTS

The incidence of progression from severe to critical illness and the 28-day mortality rate were 0 in the hUC-MSC treatment group, while 4 patients in the control group deteriorated to critical condition and received invasive ventilation; 3 of them died, and the 28-day mortality rate was 10.34%. In the hUC-MSC treatment group, the time to clinical improvement was shorter than that in the control group. Clinical symptoms of weakness and fatigue, shortness of breath, and low oxygen saturation obviously improved beginning on the third day of stem cell infusion and reached a significant difference on day 7. CRP and IL-6 levels were significantly lower from day 3 of infusion, the time for the lymphocyte count to return to the normal range was significantly faster, and lung inflammation absorption was significantly shorter on CT imaging in the hUC-MSC group than in the control group.

CONCLUSIONS

Intravenous transplantation of hUC-MSCs is a safe and effective method that can be considered a salvage and priority treatment option for severe COVID-19.

TRIAL REGISTRATION

Chinese Clinical Trial Registration; ChiCTR2000031494; Registered on 2 April 2020; http:// www.medresman.org.

DOI: 10.1186/s13287-020-01875-5
PubMed: 32811531
PubMed Central: PMC7432540

Affiliations:

République populaire de Chine

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Le document en format XML

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<author><name sortKey="Cao, Yang" sort="Cao, Yang" uniqKey="Cao Y" first="Yang" last="Cao">Yang Cao</name>
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<author><name sortKey="Yan, Jiaxin" sort="Yan, Jiaxin" uniqKey="Yan J" first="Jiaxin" last="Yan">Jiaxin Yan</name>
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<author><name sortKey="Feng, Ganzhu" sort="Feng, Ganzhu" uniqKey="Feng G" first="Ganzhu" last="Feng">Ganzhu Feng</name>
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<country xml:lang="fr">République populaire de Chine</country>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Treatment of severe COVID-19 with human umbilical cord mesenchymal stem cells.</title>
<author><name sortKey="Shu, Lei" sort="Shu, Lei" uniqKey="Shu L" first="Lei" last="Shu">Lei Shu</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory Medicine, Sir Run Run Hospital, Nanjing Medical University, Nanjing, 211166, Jiangsu, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Respiratory Medicine, Sir Run Run Hospital, Nanjing Medical University, Nanjing, 211166, Jiangsu</wicri:regionArea>
<wicri:noRegion>Jiangsu</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory Medicine, the Second Clinical Medical School of Nanjing Medical University, Nanjing, 210011, Jiangsu, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Respiratory Medicine, the Second Clinical Medical School of Nanjing Medical University, Nanjing, 210011, Jiangsu</wicri:regionArea>
<wicri:noRegion>Jiangsu</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Niu, Changming" sort="Niu, Changming" uniqKey="Niu C" first="Changming" last="Niu">Changming Niu</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Critical Care Medicine, the Second Affiliated Hospital of Nanjing Medical University, Nanjing, 210011, Jiangsu, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Critical Care Medicine, the Second Affiliated Hospital of Nanjing Medical University, Nanjing, 210011, Jiangsu</wicri:regionArea>
<wicri:noRegion>Jiangsu</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Li, Ruyou" sort="Li, Ruyou" uniqKey="Li R" first="Ruyou" last="Li">Ruyou Li</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory Medicine, Huangshi Central Hospital, Hangshi, 435000, Hubei, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Respiratory Medicine, Huangshi Central Hospital, Hangshi, 435000, Hubei</wicri:regionArea>
<wicri:noRegion>Hubei</wicri:noRegion>
</affiliation>
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<author><name sortKey="Huang, Tingrong" sort="Huang, Tingrong" uniqKey="Huang T" first="Tingrong" last="Huang">Tingrong Huang</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Nephrology, Huangshi Hospital of Traditional Chinese Medicine, Hangshi, 435000, Hubei, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Nephrology, Huangshi Hospital of Traditional Chinese Medicine, Hangshi, 435000, Hubei</wicri:regionArea>
<wicri:noRegion>Hubei</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wang, Yan" sort="Wang, Yan" uniqKey="Wang Y" first="Yan" last="Wang">Yan Wang</name>
<affiliation wicri:level="1"><nlm:affiliation>Jiangsu Cell Tech Medical Research Institute, Nanjing, 211166, Jiangsu, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Jiangsu Cell Tech Medical Research Institute, Nanjing, 211166, Jiangsu</wicri:regionArea>
<wicri:noRegion>Jiangsu</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Huang, Mao" sort="Huang, Mao" uniqKey="Huang M" first="Mao" last="Huang">Mao Huang</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory and Critical Care Medicine, the First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Respiratory and Critical Care Medicine, the First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029</wicri:regionArea>
<wicri:noRegion>210029</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ji, Ningfei" sort="Ji, Ningfei" uniqKey="Ji N" first="Ningfei" last="Ji">Ningfei Ji</name>
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<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Respiratory and Critical Care Medicine, the First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029</wicri:regionArea>
<wicri:noRegion>210029</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Zheng, You" sort="Zheng, You" uniqKey="Zheng Y" first="You" last="Zheng">You Zheng</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Nephrology, Huangshi Hospital of Traditional Chinese Medicine, Hangshi, 435000, Hubei, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Nephrology, Huangshi Hospital of Traditional Chinese Medicine, Hangshi, 435000, Hubei</wicri:regionArea>
<wicri:noRegion>Hubei</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Chen, Xiaolin" sort="Chen, Xiaolin" uniqKey="Chen X" first="Xiaolin" last="Chen">Xiaolin Chen</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory Medicine, Sir Run Run Hospital, Nanjing Medical University, Nanjing, 211166, Jiangsu, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Respiratory Medicine, Sir Run Run Hospital, Nanjing Medical University, Nanjing, 211166, Jiangsu</wicri:regionArea>
<wicri:noRegion>Jiangsu</wicri:noRegion>
</affiliation>
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<author><name sortKey="Shi, Lei" sort="Shi, Lei" uniqKey="Shi L" first="Lei" last="Shi">Lei Shi</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory Medicine, Sir Run Run Hospital, Nanjing Medical University, Nanjing, 211166, Jiangsu, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Respiratory Medicine, Sir Run Run Hospital, Nanjing Medical University, Nanjing, 211166, Jiangsu</wicri:regionArea>
<wicri:noRegion>Jiangsu</wicri:noRegion>
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<author><name sortKey="Wu, Mingjing" sort="Wu, Mingjing" uniqKey="Wu M" first="Mingjing" last="Wu">Mingjing Wu</name>
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<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Respiratory Medicine, Sir Run Run Hospital, Nanjing Medical University, Nanjing, 211166, Jiangsu</wicri:regionArea>
<wicri:noRegion>Jiangsu</wicri:noRegion>
</affiliation>
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<author><name sortKey="Deng, Kaili" sort="Deng, Kaili" uniqKey="Deng K" first="Kaili" last="Deng">Kaili Deng</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory Medicine, Sir Run Run Hospital, Nanjing Medical University, Nanjing, 211166, Jiangsu, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Respiratory Medicine, Sir Run Run Hospital, Nanjing Medical University, Nanjing, 211166, Jiangsu</wicri:regionArea>
<wicri:noRegion>Jiangsu</wicri:noRegion>
</affiliation>
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<author><name sortKey="Wei, Jing" sort="Wei, Jing" uniqKey="Wei J" first="Jing" last="Wei">Jing Wei</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory Medicine, Sir Run Run Hospital, Nanjing Medical University, Nanjing, 211166, Jiangsu, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Respiratory Medicine, Sir Run Run Hospital, Nanjing Medical University, Nanjing, 211166, Jiangsu</wicri:regionArea>
<wicri:noRegion>Jiangsu</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wang, Xueli" sort="Wang, Xueli" uniqKey="Wang X" first="Xueli" last="Wang">Xueli Wang</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory Medicine, Sir Run Run Hospital, Nanjing Medical University, Nanjing, 211166, Jiangsu, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Respiratory Medicine, Sir Run Run Hospital, Nanjing Medical University, Nanjing, 211166, Jiangsu</wicri:regionArea>
<wicri:noRegion>Jiangsu</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Cao, Yang" sort="Cao, Yang" uniqKey="Cao Y" first="Yang" last="Cao">Yang Cao</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory Medicine, Sir Run Run Hospital, Nanjing Medical University, Nanjing, 211166, Jiangsu, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Respiratory Medicine, Sir Run Run Hospital, Nanjing Medical University, Nanjing, 211166, Jiangsu</wicri:regionArea>
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</affiliation>
</author>
<author><name sortKey="Yan, Jiaxin" sort="Yan, Jiaxin" uniqKey="Yan J" first="Jiaxin" last="Yan">Jiaxin Yan</name>
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<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Respiratory Medicine, Sir Run Run Hospital, Nanjing Medical University, Nanjing, 211166, Jiangsu</wicri:regionArea>
<wicri:noRegion>Jiangsu</wicri:noRegion>
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<author><name sortKey="Feng, Ganzhu" sort="Feng, Ganzhu" uniqKey="Feng G" first="Ganzhu" last="Feng">Ganzhu Feng</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Pulmonary and Critical Care Medicine, the Second Affiliated Hospital of Nanjing Medical University, Address: No. 121 Jiangjiayuan Rd, Gulou District, Nanjing, 210011, Jiangsu, China. fenggz163@163.com.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Pulmonary and Critical Care Medicine, the Second Affiliated Hospital of Nanjing Medical University, Address: No. 121 Jiangjiayuan Rd, Gulou District, Nanjing, 210011, Jiangsu</wicri:regionArea>
<wicri:noRegion>Jiangsu</wicri:noRegion>
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<series><title level="j">Stem cell research & therapy</title>
<idno type="eISSN">1757-6512</idno>
<imprint><date when="2020" type="published">2020</date>
</imprint>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult (MeSH)</term>
<term>Aged (MeSH)</term>
<term>Betacoronavirus (isolation & purification)</term>
<term>Betacoronavirus (pathogenicity)</term>
<term>C-Reactive Protein (metabolism)</term>
<term>China (MeSH)</term>
<term>Coronavirus Infections (mortality)</term>
<term>Coronavirus Infections (therapy)</term>
<term>Coronavirus Infections (virology)</term>
<term>Female (MeSH)</term>
<term>Humans (MeSH)</term>
<term>Interleukin-6 (metabolism)</term>
<term>Lymphocyte Count (MeSH)</term>
<term>Male (MeSH)</term>
<term>Mesenchymal Stem Cell Transplantation (MeSH)</term>
<term>Mesenchymal Stem Cells (cytology)</term>
<term>Mesenchymal Stem Cells (metabolism)</term>
<term>Middle Aged (MeSH)</term>
<term>Pandemics (MeSH)</term>
<term>Pneumonia, Viral (mortality)</term>
<term>Pneumonia, Viral (therapy)</term>
<term>Pneumonia, Viral (virology)</term>
<term>Survival Rate (MeSH)</term>
<term>Thorax (diagnostic imaging)</term>
<term>Tomography, X-Ray Computed (MeSH)</term>
<term>Transplantation, Homologous (MeSH)</term>
<term>Treatment Outcome (MeSH)</term>
<term>Umbilical Cord (cytology)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adulte (MeSH)</term>
<term>Adulte d'âge moyen (MeSH)</term>
<term>Betacoronavirus (isolement et purification)</term>
<term>Betacoronavirus (pathogénicité)</term>
<term>Cellules souches mésenchymateuses (cytologie)</term>
<term>Cellules souches mésenchymateuses (métabolisme)</term>
<term>Chine (MeSH)</term>
<term>Cordon ombilical (cytologie)</term>
<term>Femelle (MeSH)</term>
<term>Humains (MeSH)</term>
<term>Infections à coronavirus (mortalité)</term>
<term>Infections à coronavirus (thérapie)</term>
<term>Infections à coronavirus (virologie)</term>
<term>Interleukine-6 (métabolisme)</term>
<term>Mâle (MeSH)</term>
<term>Numération des lymphocytes (MeSH)</term>
<term>Pandémies (MeSH)</term>
<term>Pneumopathie virale (mortalité)</term>
<term>Pneumopathie virale (thérapie)</term>
<term>Pneumopathie virale (virologie)</term>
<term>Protéine C-réactive (métabolisme)</term>
<term>Résultat thérapeutique (MeSH)</term>
<term>Sujet âgé (MeSH)</term>
<term>Taux de survie (MeSH)</term>
<term>Thorax (imagerie diagnostique)</term>
<term>Tomodensitométrie (MeSH)</term>
<term>Transplantation de cellules souches mésenchymateuses (MeSH)</term>
<term>Transplantation homologue (MeSH)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>C-Reactive Protein</term>
<term>Interleukin-6</term>
</keywords>
<keywords scheme="MESH" type="geographic" xml:lang="en"><term>China</term>
</keywords>
<keywords scheme="MESH" qualifier="cytologie" xml:lang="fr"><term>Cellules souches mésenchymateuses</term>
<term>Cordon ombilical</term>
</keywords>
<keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Mesenchymal Stem Cells</term>
<term>Umbilical Cord</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnostic imaging" xml:lang="en"><term>Thorax</term>
</keywords>
<keywords scheme="MESH" qualifier="imagerie diagnostique" xml:lang="fr"><term>Thorax</term>
</keywords>
<keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Betacoronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Betacoronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Mesenchymal Stem Cells</term>
</keywords>
<keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Coronavirus Infections</term>
<term>Pneumonia, Viral</term>
</keywords>
<keywords scheme="MESH" qualifier="mortalité" xml:lang="fr"><term>Infections à coronavirus</term>
<term>Pneumopathie virale</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Cellules souches mésenchymateuses</term>
<term>Interleukine-6</term>
<term>Protéine C-réactive</term>
</keywords>
<keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Betacoronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Betacoronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Coronavirus Infections</term>
<term>Pneumonia, Viral</term>
</keywords>
<keywords scheme="MESH" qualifier="thérapie" xml:lang="fr"><term>Infections à coronavirus</term>
<term>Pneumopathie virale</term>
</keywords>
<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Infections à coronavirus</term>
<term>Pneumopathie virale</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Coronavirus Infections</term>
<term>Pneumonia, Viral</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Female</term>
<term>Humans</term>
<term>Lymphocyte Count</term>
<term>Male</term>
<term>Mesenchymal Stem Cell Transplantation</term>
<term>Middle Aged</term>
<term>Pandemics</term>
<term>Survival Rate</term>
<term>Tomography, X-Ray Computed</term>
<term>Transplantation, Homologous</term>
<term>Treatment Outcome</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Chine</term>
<term>Femelle</term>
<term>Humains</term>
<term>Mâle</term>
<term>Numération des lymphocytes</term>
<term>Pandémies</term>
<term>Résultat thérapeutique</term>
<term>Sujet âgé</term>
<term>Taux de survie</term>
<term>Tomodensitométrie</term>
<term>Transplantation de cellules souches mésenchymateuses</term>
<term>Transplantation homologue</term>
</keywords>
<keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>République populaire de Chine</term>
</keywords>
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<front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b>
</p>
<p>COVID-19 is a highly infectious respiratory disease. No therapeutics have yet been proven effective for treating severe COVID-19.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>OBJECTIVES</b>
</p>
<p>To determine whether human umbilical cord mesenchymal stem cell infusion may be effective and safe for the treatment of severe COVID-19.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>METHODS</b>
</p>
<p>Patients with severe COVID-19 were randomly divided into 2 groups: the standard treatment group and the standard treatment plus hUC-MSC infusion group. The incidence of progression from severe to critical illness, 28-day mortality, clinical symptom improvement, time to clinical symptom improvement, hematologic indicators including C-reactive protein, lymphocyte number, and interleukin 6, and imaging changes were observed and compared between the two groups.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>MEASUREMENTS AND MAIN RESULTS</b>
</p>
<p>The incidence of progression from severe to critical illness and the 28-day mortality rate were 0 in the hUC-MSC treatment group, while 4 patients in the control group deteriorated to critical condition and received invasive ventilation; 3 of them died, and the 28-day mortality rate was 10.34%. In the hUC-MSC treatment group, the time to clinical improvement was shorter than that in the control group. Clinical symptoms of weakness and fatigue, shortness of breath, and low oxygen saturation obviously improved beginning on the third day of stem cell infusion and reached a significant difference on day 7. CRP and IL-6 levels were significantly lower from day 3 of infusion, the time for the lymphocyte count to return to the normal range was significantly faster, and lung inflammation absorption was significantly shorter on CT imaging in the hUC-MSC group than in the control group.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b>
</p>
<p>Intravenous transplantation of hUC-MSCs is a safe and effective method that can be considered a salvage and priority treatment option for severe COVID-19.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>TRIAL REGISTRATION</b>
</p>
<p>Chinese Clinical Trial Registration; ChiCTR2000031494; Registered on 2 April 2020; http:// www.medresman.org.</p>
</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">32811531</PMID>
<DateCompleted><Year>2020</Year>
<Month>08</Month>
<Day>26</Day>
</DateCompleted>
<DateRevised><Year>2020</Year>
<Month>08</Month>
<Day>26</Day>
</DateRevised>
<Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">1757-6512</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>11</Volume>
<Issue>1</Issue>
<PubDate><Year>2020</Year>
<Month>08</Month>
<Day>18</Day>
</PubDate>
</JournalIssue>
<Title>Stem cell research & therapy</Title>
<ISOAbbreviation>Stem Cell Res Ther</ISOAbbreviation>
</Journal>
<ArticleTitle>Treatment of severe COVID-19 with human umbilical cord mesenchymal stem cells.</ArticleTitle>
<Pagination><MedlinePgn>361</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1186/s13287-020-01875-5</ELocationID>
<Abstract><AbstractText Label="BACKGROUND">COVID-19 is a highly infectious respiratory disease. No therapeutics have yet been proven effective for treating severe COVID-19.</AbstractText>
<AbstractText Label="OBJECTIVES">To determine whether human umbilical cord mesenchymal stem cell infusion may be effective and safe for the treatment of severe COVID-19.</AbstractText>
<AbstractText Label="METHODS">Patients with severe COVID-19 were randomly divided into 2 groups: the standard treatment group and the standard treatment plus hUC-MSC infusion group. The incidence of progression from severe to critical illness, 28-day mortality, clinical symptom improvement, time to clinical symptom improvement, hematologic indicators including C-reactive protein, lymphocyte number, and interleukin 6, and imaging changes were observed and compared between the two groups.</AbstractText>
<AbstractText Label="MEASUREMENTS AND MAIN RESULTS">The incidence of progression from severe to critical illness and the 28-day mortality rate were 0 in the hUC-MSC treatment group, while 4 patients in the control group deteriorated to critical condition and received invasive ventilation; 3 of them died, and the 28-day mortality rate was 10.34%. In the hUC-MSC treatment group, the time to clinical improvement was shorter than that in the control group. Clinical symptoms of weakness and fatigue, shortness of breath, and low oxygen saturation obviously improved beginning on the third day of stem cell infusion and reached a significant difference on day 7. CRP and IL-6 levels were significantly lower from day 3 of infusion, the time for the lymphocyte count to return to the normal range was significantly faster, and lung inflammation absorption was significantly shorter on CT imaging in the hUC-MSC group than in the control group.</AbstractText>
<AbstractText Label="CONCLUSIONS">Intravenous transplantation of hUC-MSCs is a safe and effective method that can be considered a salvage and priority treatment option for severe COVID-19.</AbstractText>
<AbstractText Label="TRIAL REGISTRATION">Chinese Clinical Trial Registration; ChiCTR2000031494; Registered on 2 April 2020; http:// www.medresman.org.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Shu</LastName>
<ForeName>Lei</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Department of Respiratory Medicine, Sir Run Run Hospital, Nanjing Medical University, Nanjing, 211166, Jiangsu, China.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Respiratory Medicine, the Second Clinical Medical School of Nanjing Medical University, Nanjing, 210011, Jiangsu, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Niu</LastName>
<ForeName>Changming</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Department of Critical Care Medicine, the Second Affiliated Hospital of Nanjing Medical University, Nanjing, 210011, Jiangsu, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Li</LastName>
<ForeName>Ruyou</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>Department of Respiratory Medicine, Huangshi Central Hospital, Hangshi, 435000, Hubei, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Huang</LastName>
<ForeName>Tingrong</ForeName>
<Initials>T</Initials>
<AffiliationInfo><Affiliation>Department of Nephrology, Huangshi Hospital of Traditional Chinese Medicine, Hangshi, 435000, Hubei, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wang</LastName>
<ForeName>Yan</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>Jiangsu Cell Tech Medical Research Institute, Nanjing, 211166, Jiangsu, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Huang</LastName>
<ForeName>Mao</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Department of Respiratory and Critical Care Medicine, the First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Ji</LastName>
<ForeName>Ningfei</ForeName>
<Initials>N</Initials>
<AffiliationInfo><Affiliation>Department of Respiratory and Critical Care Medicine, the First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zheng</LastName>
<ForeName>You</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>Department of Nephrology, Huangshi Hospital of Traditional Chinese Medicine, Hangshi, 435000, Hubei, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Chen</LastName>
<ForeName>Xiaolin</ForeName>
<Initials>X</Initials>
<AffiliationInfo><Affiliation>Department of Respiratory Medicine, Sir Run Run Hospital, Nanjing Medical University, Nanjing, 211166, Jiangsu, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Shi</LastName>
<ForeName>Lei</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Department of Respiratory Medicine, Sir Run Run Hospital, Nanjing Medical University, Nanjing, 211166, Jiangsu, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wu</LastName>
<ForeName>Mingjing</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Department of Respiratory Medicine, Sir Run Run Hospital, Nanjing Medical University, Nanjing, 211166, Jiangsu, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Deng</LastName>
<ForeName>Kaili</ForeName>
<Initials>K</Initials>
<AffiliationInfo><Affiliation>Department of Respiratory Medicine, Sir Run Run Hospital, Nanjing Medical University, Nanjing, 211166, Jiangsu, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wei</LastName>
<ForeName>Jing</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Department of Respiratory Medicine, Sir Run Run Hospital, Nanjing Medical University, Nanjing, 211166, Jiangsu, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wang</LastName>
<ForeName>Xueli</ForeName>
<Initials>X</Initials>
<AffiliationInfo><Affiliation>Department of Respiratory Medicine, Sir Run Run Hospital, Nanjing Medical University, Nanjing, 211166, Jiangsu, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Cao</LastName>
<ForeName>Yang</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>Department of Respiratory Medicine, Sir Run Run Hospital, Nanjing Medical University, Nanjing, 211166, Jiangsu, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Yan</LastName>
<ForeName>Jiaxin</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Department of Respiratory Medicine, Sir Run Run Hospital, Nanjing Medical University, Nanjing, 211166, Jiangsu, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Feng</LastName>
<ForeName>Ganzhu</ForeName>
<Initials>G</Initials>
<AffiliationInfo><Affiliation>Department of Pulmonary and Critical Care Medicine, the Second Affiliated Hospital of Nanjing Medical University, Address: No. 121 Jiangjiayuan Rd, Gulou District, Nanjing, 210011, Jiangsu, China. fenggz163@163.com.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<GrantList CompleteYN="Y"><Grant><GrantID>81670013</GrantID>
<Agency>National Natural Science Foundation of China</Agency>
<Country>International</Country>
</Grant>
<Grant><GrantID>BE2020616</GrantID>
<Agency>Key Research and Development Project of Jiangsu Province</Agency>
<Country>International</Country>
</Grant>
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<PublicationType UI="D016449">Randomized Controlled Trial</PublicationType>
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<ArticleDate DateType="Electronic"><Year>2020</Year>
<Month>08</Month>
<Day>18</Day>
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<MedlineTA>Stem Cell Res Ther</MedlineTA>
<NlmUniqueID>101527581</NlmUniqueID>
<ISSNLinking>1757-6512</ISSNLinking>
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<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D015850">Interleukin-6</NameOfSubstance>
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<Chemical><RegistryNumber>9007-41-4</RegistryNumber>
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<SupplMeshName Type="Organism" UI="C000656484">severe acute respiratory syndrome coronavirus 2</SupplMeshName>
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<MeshHeading><DescriptorName UI="D002097" MajorTopicYN="N">C-Reactive Protein</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
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<MeshHeading><DescriptorName UI="D018352" MajorTopicYN="N">Coronavirus Infections</DescriptorName>
<QualifierName UI="Q000401" MajorTopicYN="N">mortality</QualifierName>
<QualifierName UI="Q000628" MajorTopicYN="Y">therapy</QualifierName>
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<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015850" MajorTopicYN="N">Interleukin-6</DescriptorName>
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</MeshHeading>
<MeshHeading><DescriptorName UI="D018655" MajorTopicYN="N">Lymphocyte Count</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D045164" MajorTopicYN="Y">Mesenchymal Stem Cell Transplantation</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D059630" MajorTopicYN="N">Mesenchymal Stem Cells</DescriptorName>
<QualifierName UI="Q000166" MajorTopicYN="N">cytology</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName>
</MeshHeading>
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</MeshHeading>
<MeshHeading><DescriptorName UI="D011024" MajorTopicYN="N">Pneumonia, Viral</DescriptorName>
<QualifierName UI="Q000401" MajorTopicYN="N">mortality</QualifierName>
<QualifierName UI="Q000628" MajorTopicYN="Y">therapy</QualifierName>
<QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015996" MajorTopicYN="N">Survival Rate</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D013909" MajorTopicYN="N">Thorax</DescriptorName>
<QualifierName UI="Q000000981" MajorTopicYN="N">diagnostic imaging</QualifierName>
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<MeshHeading><DescriptorName UI="D014057" MajorTopicYN="N">Tomography, X-Ray Computed</DescriptorName>
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<MeshHeading><DescriptorName UI="D014184" MajorTopicYN="N">Transplantation, Homologous</DescriptorName>
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<MeshHeading><DescriptorName UI="D016896" MajorTopicYN="N">Treatment Outcome</DescriptorName>
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<QualifierName UI="Q000166" MajorTopicYN="Y">cytology</QualifierName>
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<Keyword MajorTopicYN="Y">Coronavirus disease-19 (COVID-19)</Keyword>
<Keyword MajorTopicYN="Y">Coronavirus pneumonia</Keyword>
<Keyword MajorTopicYN="Y">Human umbilical cord mesenchymal stem cells</Keyword>
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</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year>
<Month>04</Month>
<Day>20</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2020</Year>
<Month>08</Month>
<Day>04</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="revised"><Year>2020</Year>
<Month>07</Month>
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	Serveur d'exploration sur la COVID chez les séniors
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Serveur d'exploration sur la COVID chez les séniors

Treatment of severe COVID-19 with human umbilical cord mesenchymal stem cells.

Treatment of severe COVID-19 with human umbilical cord mesenchymal stem cells.

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